Acute generalized exanthematous pustulosis - Akute Veralgemeende Exanthematous Pustulose
Akute Veralgemeende Exanthematous Pustulose (Acute generalized exanthematous pustulosis) (AGEP) is 'n seldsame velreaksie wat in 90% van gevalle verband hou met medikasietoediening. akute veralgemeende exanthematous pustulose (acute generalized exanthematous pustulosis) word gekenmerk deur skielike veluitbarstings wat gemiddeld vyf dae na die begin van 'n medikasie verskyn. Hierdie uitbarstings is pustules, dit wil sê klein rooi wit of rooi uitbarsting van die vel wat troebel of etterige materiaal (etter) bevat. Die velletsels verdwyn gewoonlik binne 1–3 dae nadat die aanstootlike medikasie gestaak is.
☆ In die 2022 Stiftung Warentest-resultate van Duitsland was verbruikerstevredenheid met ModelDerm net effens laer as met betaalde telemedisyne-konsultasies.
Wydverspreide letsels met eriteem en pustules verskyn skielik.
References
Acute generalized exanthematous pustulosis (AGEP) is 'n velreaksie gekenmerk deur klein, etter-gevulde knoppe op 'n rooi velbasis. Dit gebeur gewoonlik wanneer iemand sekere medikasie, soos antibiotika, neem en vinnig oor die liggaam versprei. Nadat die aktiveermedikasie gestaak is, verdwyn die simptome gewoonlik binne twee weke, wat dikwels 'n mate van velafskeiding laat. Alhoewel dit gewoonlik nie ernstig is nie en beperk is tot die vel, kan ernstige gevalle saam met ander ernstige velreaksies soos Stevens-Johnson syndrome of toxic epidermal necrolysis geklassifiseer word. Behandeling is hoofsaaklik ondersteunende sorg, en die prognose vir volledige oplossing van die siekte is gewoonlik uitstekend.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Acute generalized exanthematous pustulosis (AGEP) is an adverse cutaneous reaction characterized by sterile pinpoint nonfollicular pustules atop an erythematous background. Symptoms most often occur in the setting of medication exposure, such as systemic antibiotics, rapidly become generalized, followed by desquamation and resolution within about two weeks of discontinuing the offending trigger. Although mostly self-limited without systemic involvement, severe cases are classified alongside other cutaneous adverse reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug reaction with eosinophilia and systemic symptoms. Treatment is primarily supportive, and the prognosis for complete resolution is excellent.
Recent experimental data reviewed herein are supportive of an early role of drug-induced innate immune activation and innate cytokines such as interleukin (IL)-1, IL-36, and IL-17 in the pathogenesis of AGEP. This explains the rapid onset and neutrophilic character of the cutaneous inflammation.
’n 76-jarige man het na die noodkamer gekom omdat sy vel die afgelope twee dae verander het. Dokters het rooi kolle en verhewe areas op sy romp en arms en bene gevind. Soos die tyd aangegaan het, het hierdie kolle saamgevoeg, en hy het puisie-agtige knoppe in die rooi areas ontwikkel. Toetse het hoë witbloedseltelling getoon met baie van 'n tipe genaamd neutrofiele, en verhoogde vlakke van C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
A 76-year-old male patient presented as an emergency due to a 2-day history of skin changes. Physical examination revealed disseminated erythematous macules and plaques on the trunk and extremities. In the further course, confluence of the macules and non-follicular pustulosis developed in the area of erythema. Laboratory tests revealed leukocytosis with neutrophils and elevated C-reactive protein.
